Association between vitamin D and bone mineral density in post-menopausal women with metabolic syndrome
Internal Medicine
Jolanta Dadonienė
Alma Čypienė
Egidija Rinkūnienė
Jolita Badarienė
Jelizaveta Burca
Ieva Sakaitė
Goda Kalinauskaitė
Vaiva Kumpauskaitė
Aleksandras Laucevičius
Published 2015-05-18


vitamin D
bone mineral density
metabolic syndrome

How to Cite

Dadonienė J., Čypienė A., Rinkūnienė E., Badarienė J., Burca J., Sakaitė I., Kalinauskaitė G., Kumpauskaitė V. and Laucevičius A. (2015) “Association between vitamin D and bone mineral density in post-menopausal women with metabolic syndrome”, Acta medica Lituanica, 22(1), pp. 7-14. doi: 10.6001/actamedica.v22i1.3074.


Background. The aim of this study was to identify the relation between vitamin D level and mineral bone density in post-menopausal women with metabolic syndrome. Materials and methods. This study included 100 post-menopausal women at age between 50 and 65 with metabolic syndrome. All participants underwent anthropometric measurements. Laboratory tests were performed to determine lipid profile, serum glucose, creatinine, C-reactive protein, vitamin D (25(OH) D), ionized calcium concentration and urine albumin / creatinine ratio. Bone mineral density of the lumbar spine (L1– L4) and total hip was measured by dual-energy X-ray absorptiometry. Results. According to the vitamin D concentration level in the blood all women were divided into four groups: the average failure was observed in 57%, mild failure in 33%, severe failure in 5%; and only 5% of women had normal vitamin levels. The mean 25(OH) D level was 47.40  ±  16.91  nmol/l. According to bone densitometry we found that 77% of all participants had normal bone mineral density, 22% had osteopenia and 5% were diagnosed with osteoporosis. No correlation was found between bone mineral density and 25(OH)  D levels. We found a weak positive correlation between high density lipoprotein cholesterol and 25(OH) D (r = 0.3, p < 0.05) but no significant difference between 25(OH) D and other lipoproteins, calcium ions, glucose, C-reactive protein and urine albumin / creatinine ratio. Conclusions. Hypovitaminosis D is very common among post-menopausal women with metabolic syndrome. No relation was found between the 25(OH) D level and the bone mineral density.
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