Abstract
Background. This study describes antimicrobial, anticancer and antioxidant properties of Sauropus androgynus stem extract. The main objective of the present study was to reveal the potential of S. androgynus strip to be used as a medicinal drug.
Materials and methods. The antimicrobial properties of S. androgynus stem extract against Aeromonas hydrophila, Escherichia coli, Edwardsiella tarda, Flavobacterium sp., Klebsiella sp., Salmonella sp., Vibrio alginolyticus, V. parahaemolyticus, V. cholerae and Pseudomonas aeruginosa were revealed by using the broth micro-dilution method, whereas the anticancer effects of the extract was determined with a colorimetric MTT (tetrazolium) assay against human breast adenocarcinoma (MCF-7). The antioxidant activity of the plant extract was characterized also by using a α, α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging method. Finally, chemical compounds of the plant extract were screened and identified by using gas chromatography – mass spectrometry (GC–MS).
Results. The minimum inhibitory concentration (MIC) values ranged from 7.81 to 62.5 mg/l in which the plant extract was found to inhibit the growth of Edwardsiella tarda, Escherichia coli, Flavobacterium sp., Pseudomonas aeruginosa and Vibrio cholerae at 7.81 mg/l, Klebsiella sp., Aeromonas hydrophila and Vibrio alginolyticus at 15.6 mg/l, and it was able to control the growth of Salmonella sp. and Vibrio parahaemolyticus at 62.5 mg/l. The results of the present study has shown S. androgynus stem extract to possess a high antimicrobial activity and a moderate antioxidant activity (inhibition concentration 50%; IC50 of DPPH is 8 ppt), but no anticancer activity. A total of 34 compounds were identified in the plant extract in which the major compounds were 9, 12, 15-octadecatrienoic acid, methyl ester, (Z, Z, Z)- (14.48%) and phytol (13.08%).
Conclusions. S. androgynus stem extract can be used as an antimicrobial and antioxidant agents.
Keywords: antimicrobial, antioxidant, anticancer, chemical compound, Sauropus androgynus stem
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Mārtiņš Vaivads,
Ilze Akota,
Māra Pilmane,
Immunohistochemical Evaluation of BARX1, DLX4, FOXE1, HOXB3, and MSX2 in Non-syndromic Cleft-affected Tissue
,
Acta medica Lituanica: Vol. 29 No. 2 (2022): Acta medica Lituanica
-
Petros Galanis,
Irene Vraka,
Olga Siskou,
Olympia Konstantakopoulou,
Aglaia Katsiroumpa,
Ioannis Moisoglou,
Daphne Kaitelidou,
Predictors of Real-World Parents’ Acceptance to Vaccinate Their Children Against the COVID-19
,
Acta medica Lituanica: Vol. 29 No. 1 (2022): Acta medica Lituanica
-
Roberts Gobergs,
Elza Salputra,
Ingūna Lubaua,
Hypoplastic left heart syndrome: a review
,
Acta medica Lituanica: Vol. 23 No. 2 (2016)
-
Sohil Pothiawala,
Bell’s Palsy After Second Dose of Moderna COVID-19 Vaccine: Coincidence or Causation?
,
Acta medica Lituanica: Vol. 28 No. 2 (2021): Acta medica Lituanica
-
Ieva Rudinskaitė,
Eglė Mačiūtė,
Giedrė Gudžiūnaitė,
Greta Gerulaitytė,
Burnout Syndrome Amongst Medicine Students in Lithuania and Germany
,
Acta medica Lituanica: Vol. 27 No. 2 (2020): Acta medica Lituanica
-
Gabrielė Linkaitė,
Mantas Riauka,
Ignė Bunevičiūtė,
Saulius Vosylius,
Evaluation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for the patients in the intensive care unit
,
Acta medica Lituanica: Vol. 25 No. 1 (2018)
-
Agnė Dzingutė,
Gaivilė Pileičikienė,
Aušra Baltrušaitytė,
Gediminas Skirbutis,
Evaluation of the relationship between the occlusion parameters and symptoms of the temporomandibular joint disorder
,
Acta medica Lituanica: Vol. 24 No. 3 (2017)
-
Dovilė Gabartaitė,
Dovilė Jančauskaitė,
Violeta Mikštienė,
Eglė Preikšaitienė,
Rimvydas Norvilas,
Nomeda Valevičienė,
Germanas Marinskis,
Audrius Aidietis,
Jūratė Barysienė,
Two Novel Variants in Genes of Arrhythmogenic Right Ventricular Cardiomyopathy – a Case Report
,
Acta medica Lituanica: Vol. 28 No. 1 (2021): Acta medica Lituanica
-
Dominykas Varnas,
Augustina Jankauskienė,
Pneumocystis Jirovecii Pneumonia in a Kidney Transplant Recipient 13 Months after Transplantation: A Case Report and Literature Review
,
Acta medica Lituanica: Vol. 28 No. 1 (2021): Acta medica Lituanica
-
Adelė Butėnaitė,
Robertas Strumila,
Aistė Lengvenytė,
Indrė Kotryna Pakutkaitė,
Aušra Morkūnienė,
Aušra Matulevičienė,
Edgaras Dlugauskas,
Algirdas Utkus,
Significant Association Between Huntingtin Gene Mutation and Prevalence of Hopelessness, Depression and Anxiety Symptoms
,
Acta medica Lituanica: Vol. 28 No. 1 (2021): Acta medica Lituanica