Abstract
Background. This study describes antimicrobial, anticancer and antioxidant properties of Sauropus androgynus stem extract. The main objective of the present study was to reveal the potential of S. androgynus strip to be used as a medicinal drug.
Materials and methods. The antimicrobial properties of S. androgynus stem extract against Aeromonas hydrophila, Escherichia coli, Edwardsiella tarda, Flavobacterium sp., Klebsiella sp., Salmonella sp., Vibrio alginolyticus, V. parahaemolyticus, V. cholerae and Pseudomonas aeruginosa were revealed by using the broth micro-dilution method, whereas the anticancer effects of the extract was determined with a colorimetric MTT (tetrazolium) assay against human breast adenocarcinoma (MCF-7). The antioxidant activity of the plant extract was characterized also by using a α, α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging method. Finally, chemical compounds of the plant extract were screened and identified by using gas chromatography – mass spectrometry (GC–MS).
Results. The minimum inhibitory concentration (MIC) values ranged from 7.81 to 62.5 mg/l in which the plant extract was found to inhibit the growth of Edwardsiella tarda, Escherichia coli, Flavobacterium sp., Pseudomonas aeruginosa and Vibrio cholerae at 7.81 mg/l, Klebsiella sp., Aeromonas hydrophila and Vibrio alginolyticus at 15.6 mg/l, and it was able to control the growth of Salmonella sp. and Vibrio parahaemolyticus at 62.5 mg/l. The results of the present study has shown S. androgynus stem extract to possess a high antimicrobial activity and a moderate antioxidant activity (inhibition concentration 50%; IC50 of DPPH is 8 ppt), but no anticancer activity. A total of 34 compounds were identified in the plant extract in which the major compounds were 9, 12, 15-octadecatrienoic acid, methyl ester, (Z, Z, Z)- (14.48%) and phytol (13.08%).
Conclusions. S. androgynus stem extract can be used as an antimicrobial and antioxidant agents.
Keywords: antimicrobial, antioxidant, anticancer, chemical compound, Sauropus androgynus stem
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Luize Auzina,
Elina Skuja,
Toms Janis Safranovs,
Valts Ozolins,
Helmuts Kidikas,
Gita Taurina,
Inguna Lubaua,
A giant arteriovenous malformation and fistula in a newborn with Parkes Weber syndrome. Case report
,
Acta medica Lituanica: Vol. 27 No. 2 (2020): Acta medica Lituanica
-
Laura Steponavičienė,
Rūta Briedienė,
Rasa Vansevičiūtė-Petkevičienė,
Daiva Gudavičienė,
Ieva Vincerževskienė,
Breast cancer screening program in Lithuania: trends in breast cancer mortality before and during the introduction of the mammography screening programme
,
Acta medica Lituanica: Vol. 27 No. 2 (2020): Acta medica Lituanica
-
Ratko Delić,
Pregnancy in a Unicornuate Uterus with Non-Communicating Rudimentary Horn: Diagnostic and Therapeutic Challenges
,
Acta medica Lituanica: Vol. 27 No. 2 (2020): Acta medica Lituanica
-
Jūratė Gudaitytė,
Dominykas Dvylys,
Indrė Šimeliūnaitė,
Anaesthetic challenges in cancer patients: current therapies and pain management
,
Acta medica Lituanica: Vol. 24 No. 2 (2017)
-
Vilija Malinauskienė,
Lina Bernotaitė,
The Impact of Event Scale – Revised: psychometric properties of the Lithuanian version in a sample of employees exposed to workplace bullying
,
Acta medica Lituanica: Vol. 23 No. 3 (2016)
-
Daniel Paramythiotis,
Eleni Karlafti,
Georgia Fotiadou,
Maria Charalampidou,
Anestis Karakatsanis,
Aristeidis Ioannidis,
Antonios Michalopoulos,
Pancreatic Intraductal Papillary Mucinous Neoplasms: A Narrative Review
,
Acta medica Lituanica: Vol. 30 No. 1 (2023): Acta medica Lituanica
-
Olga Rimdenoka,
Māra Pilmane,
Evaluation of TGF-β1 and EGFR in Cleft Affected Lip Mucosa
,
Acta medica Lituanica: Vol. 28 No. 1 (2021): Acta medica Lituanica
-
Ugur Gonlugur,
Tanseli Gonlugur,
Sule Ozer,
Middle Lobe Syndrome Associated with Bronchial Anthracofibrosis
,
Acta medica Lituanica: Vol. 27 No. 2 (2020): Acta medica Lituanica
-
Živilė Gudlevičienė,
Raminta Baušytė,
Evelina Dagytė,
Danutė Balkelienė,
Algirdas Utkus,
Diana Ramašauskaitė,
The First Live Birth in Lithuania After Application of Preimplantation Genetic Testing
,
Acta medica Lituanica: Vol. 27 No. 2 (2020): Acta medica Lituanica
-
Austėja Voiniušytė,
Miglė Černiauskaitė,
Virginija Paliulytė,
Rūta Einikytė,
Diana Ramašauskaitė,
Vaccination Against COVID-19 Disease During Pregnancy
,
Acta medica Lituanica: Vol. 29 No. 1 (2022): Acta medica Lituanica