Abstract
Background. This study describes antimicrobial, anticancer and antioxidant properties of Sauropus androgynus stem extract. The main objective of the present study was to reveal the potential of S. androgynus strip to be used as a medicinal drug.
Materials and methods. The antimicrobial properties of S. androgynus stem extract against Aeromonas hydrophila, Escherichia coli, Edwardsiella tarda, Flavobacterium sp., Klebsiella sp., Salmonella sp., Vibrio alginolyticus, V. parahaemolyticus, V. cholerae and Pseudomonas aeruginosa were revealed by using the broth micro-dilution method, whereas the anticancer effects of the extract was determined with a colorimetric MTT (tetrazolium) assay against human breast adenocarcinoma (MCF-7). The antioxidant activity of the plant extract was characterized also by using a α, α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging method. Finally, chemical compounds of the plant extract were screened and identified by using gas chromatography – mass spectrometry (GC–MS).
Results. The minimum inhibitory concentration (MIC) values ranged from 7.81 to 62.5 mg/l in which the plant extract was found to inhibit the growth of Edwardsiella tarda, Escherichia coli, Flavobacterium sp., Pseudomonas aeruginosa and Vibrio cholerae at 7.81 mg/l, Klebsiella sp., Aeromonas hydrophila and Vibrio alginolyticus at 15.6 mg/l, and it was able to control the growth of Salmonella sp. and Vibrio parahaemolyticus at 62.5 mg/l. The results of the present study has shown S. androgynus stem extract to possess a high antimicrobial activity and a moderate antioxidant activity (inhibition concentration 50%; IC50 of DPPH is 8 ppt), but no anticancer activity. A total of 34 compounds were identified in the plant extract in which the major compounds were 9, 12, 15-octadecatrienoic acid, methyl ester, (Z, Z, Z)- (14.48%) and phytol (13.08%).
Conclusions. S. androgynus stem extract can be used as an antimicrobial and antioxidant agents.
Keywords: antimicrobial, antioxidant, anticancer, chemical compound, Sauropus androgynus stem
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Evangelos N. Symeonidis,
Chrysovalantis Toutziaris,
Antonios Katsimantas,
Georgios Dimitriadis,
Incidental Detection of Preputial Calculus in a Patient with Partial Phimosis: Is it as Rare as We Believed?
,
Acta medica Lituanica: Vol. 28 No. 1 (2021): Acta medica Lituanica
-
Aistė Aleknaitė,
Monika Andrijauskaitė,
Justė Latauskienė,
Viktorija Andrejevaitė,
Elektroninės cigaretės: naujas būdas mesti rūkyti ar nauja grėsmė?
,
Acta medica Lituanica: Vol. 23 No. 1 (2016)
-
Nadežda Lachej,
Violeta Jonušienė,
Augustina Mažeikė,
Aušra Sasnauskienė,
Daiva Dabkevičienė,
Julija Šimienė,
Kęstutis Sužiedėlis,
Janina Didžiapetrienė,
Changes in the expression of Notch and Wnt signalling molecules in human endometrial cancer
,
Acta medica Lituanica: Vol. 26 No. 3 (2019): Acta Medica Lituanica
-
Audrius Dulskas,
Mantas Trakymas,
Jolita Gibavičienė,
Vytautas Čepulis,
Agnė Čižauskaitė,
Narimantas Samalavičius,
Cutaneous Melanoma with Tonsillar Metastasis: Treatment with Cryoablation
,
Acta medica Lituanica: Vol. 29 No. 1 (2022): Acta medica Lituanica
-
Neda Gendvilaitė,
Julius Drachneris,
Tomas Poškus,
Lymphangioma of the Mesentery: Case Report and Review of the Literature
,
Acta medica Lituanica: Vol. 28 No. 1 (2021): Acta medica Lituanica
-
Vladislav Lisovski,
Mindaugas Minderis,
Intraneural ganglion cyst: a case report and a review of the literature
,
Acta medica Lituanica: Vol. 26 No. 2 (2019): Acta Medica Lituanica
-
Bunyamin Güney,
Emrah Doğan,
Murat Yunus Özdemir,
The Osteochondroma as a Cause of Ischiofemoral Impingement – First Case Series
,
Acta medica Lituanica: Vol. 28 No. 1 (2021): Acta medica Lituanica
-
Eglė Stukaitė-Ruibienė,
Živilė Gudlevičienė,
Andrė Amšiejienė,
Evelina Dagytė,
Rimantas Gricius,
Kristina Grigalionienė,
Algirdas Utkus,
Diana Ramašauskaitė,
Implementation and Evaluation of Preimplantation Genetic Testing at Vilnius University Hospital Santaros Klinikos
,
Acta medica Lituanica: Vol. 29 No. 2 (2022): Acta medica Lituanica
-
Igor Lakhno,
The Insight into Obstetric Care near the Front Line in Kharkiv
,
Acta medica Lituanica: Vol. 29 No. 2 (2022): Acta medica Lituanica
-
Audrius VASILIAUSKAS,
Laima LEONAVIČIENĖ,
Dalia VAITKIENĖ,
Rūta BRADŪNAITĖ,
Aloyza LUKŠIENĖ,
Anti-inflammatory effects of Aesculus hippocastanum L. tincture and the pro-/antioxidant bodily state of rats with adjuvant arthritis
,
Acta medica Lituanica: Vol. 17 No. 3-4 (2010)