A general biochemical kinetics data fitting algorithm for quasi-steady-state detection
Justinas V. Daugmaudis
Vilnius University
Audrius Laurynėnas
Vilnius University
Juozas Kulys
Vilnius University
Feliksas Ivanauskas
Vilnius University
Published 2016-12-15


biochemical kinetics
differential equations
curve fitting
reaction rate constants

How to Cite

Daugmaudis J. V., Laurynėnas A., Kulys J. and Ivanauskas F. (2016) “A general biochemical kinetics data fitting algorithm for quasi-steady-state detection”, Lietuvos matematikos rinkinys, 57(A), pp. 12–17. doi: 10.15388/LMR.A.2016.03.


We develop a general algorithm for fitting the biochemical kinetics data. The developed algorithm searches and analyzes numerous minima. This approach allows us to analyze biochemical data without a priori quasi-steady-state assumptions. The algorithm allows us to treat the biochemical kinetics data that has varying degree of steadiness. We test the approach by analyzing experiment data from 4-nitrophenyl phosphate hydrolysis with alkaline phosphatase.


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