Evaluation of Quality of Life in Patients with Chronic Leg Wounds: Can Platelet-rich Plasma Therapy Help?
Original research work
Domantas Rainys
Medical Academy of Lithuanian University of Health Sciences, Lithuania
Adas Čepas
Medical Academy of Lithuanian University of Health Sciences, Lithuania
Rytis Rimdeika
Medical Academy of Lithuanian University of Health Sciences, Lithuania
Published 2020-06-10
https://doi.org/10.15388/LietChirur.2020.19.24
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Keywords

chronic wound
skin ulcer
platelet-rich plasma
quality of life
regenerative medicine

How to Cite

1.
Rainys D, Čepas A, Rimdeika R. Evaluation of Quality of Life in Patients with Chronic Leg Wounds: Can Platelet-rich Plasma Therapy Help?. LS [Internet]. 2020Jun.10 [cited 2022Aug.13];19(1-2):42-0. Available from: https://www.journals.vu.lt/lietuvos-chirurgija/article/view/18367

Abstract

Aim. The aim of the study was to evaluate and compare the quality of life (QoL) using platelet-rich plasma gel (PRP) and conventional treatment of chronic leg wounds. Methods. Randomized clinical trial was carried out in Hospital of Lithuanian University of Health Sciences Kaunas Clinics during 2014–2018. Patients (n = 69) included in the study were randomly grouped into 2 groups: 1) PRP, 2) Control. SF-36 questionnaire was used to evaluate QoL, visual analog scale was used to evaluate persistent pain associated with ulcer and wound exudate volume was also evaluated. Statistical analysis were performed with SPSS 23.0 package. Results. Patients in PRP group at the end of the treatment rated their QoL over control group patients (p < 0.05). Wound associated pain (PRP – 1.54; control – 2.85; p = 0.015) and pain associated sleep disturbance (p < 0.001) was lower in PRP group patients. Wound exudate volume was lower in PRP group patients at the end of the treatment (p < 0.05). Conclusion. The treatment with PRP is associated with less wound associated pain, less-common sleep disturbance, reduced wound secretion and improved quality of life compared to conventional treatment.

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