. The present investigation deals with the disease in the prey population having significant role in curbing the dynamical behaviour of the system of prey-predator interactions from both ecological and mathematical point of view. The predator-prey model introduced by Cosner et al. [1] has been wisely modified in the present work based on the biological point of considerations. Here one introduces the disease which may spread among the prey species only. Following the formulation of the model, all the equilibria are systematically analyzed and the existence of a Hopf bifurcation at the interior equilibrium has been duly carried out through their graphical representations with appropriate discussion in order to validate the applicability of the system under consideration