Theory and computational study of electrophoretic ion separation and focusing in microfluidic channels
Oleksiy V. Klymenko
Ecole Normale Supérieure, France
Christian Amatore
Ecole Normale Supérieure, France
Wen Sun
Xiamen University, China
Yong-Liang Zhou
Xiamen University, China
Zhao-Wu Tian
Xiamen University, China
Irina Svir
Ecole Normale Supérieure, France
Published 2012-10-25


analytical separation
ion-conducting membranes
2D simulation

How to Cite

Klymenko O. V., Amatore C., Sun W., Zhou Y.-L., Tian Z.-W. and Svir I. (2012) “Theory and computational study of electrophoretic ion separation and focusing in microfluidic channels”, Nonlinear Analysis: Modelling and Control, 17(4), pp. 431-447. doi: 10.15388/NA.17.4.14049.


In this work we describe the theory and 2D simulation of ion separation and focusing in a new concept of microfluidic separation device. The principle of the method of ion focusing is classical in the sense that it consists in opposing a hydrodynamic transport ensured by the solution flow to an electrophoretic driving force so that any ionic sample results poised within the microchannel at the point where the two forces equilibrate. The originality of the concept investigated here relies on the fact that thanks to the use of an ion-conducting membrane of variable thickness in electrical contact with the channel the electrophoretic force is varied continuously all along the channel length. Similarly, changing the geometric shape of the membrane allows a facile optimization of the device separation and focusing properties.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Please read the Copyright Notice in Journal Policy