Global dynamics for a class of infection-age model with nonlinear incidence
Articles
Yuji Li
Army Engineering University
Rui Xu
Shanxi University
Jiazhe Jiazhe
Army Engineering University
Published 2018-12-14
https://doi.org/10.15388/NA.2019.1.4
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Keywords

age structure
saturation incidence
asymptotic smoothness
Lyapunov functional
global stability

How to Cite

Li, Y., Xu, R. and Jiazhe, J. (2018) “Global dynamics for a class of infection-age model with nonlinear incidence”, Nonlinear Analysis: Modelling and Control, 24(1), pp. 47–72. doi:10.15388/NA.2019.1.4.

Abstract

In this paper, we propose an HBV viral infection model with continuous age structure and nonlinear incidence rate. Asymptotic smoothness of the semi-flow generated by the model is studied. Then we caculate the basic reproduction number and prove that it is a sharp threshold determining whether the infection dies out or not. We give a rigorous mathematical analysis on uniform persistence by reformulating the system as a system of Volterra integral equations. The global dynamics of the model is established by using suitable Lyapunov functionals and LaSalle's invariance principle. We further investigate the global behaviors of the HBV viral infection model with saturation incidence through numerical simulations.

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